 |
Technology
CritiView monitors are based on proprietary, patented technology for
measuring key parameters of tissue viability continuously, simultaneously
and in real-time with a single probe. CritiView simultaneously measures
mitochondrial NADH, blood oxygenation, microcirculatory blood flow
and tissue reflectance.
Tissue viability depends on the balance between the oxygen supply
to, and the oxygen demand by the body's organs. Microcirculatory
blood flow and volume as well as local blood oxygenation,
represent the regulatory process of O2 supply and delivery to the
tissue.
An intracellular biological factor - mitochondrial NADH redox state
- serves as marker of the energy generation process and oxygen balance
in the cell. Imbalances in the energy regime will be translated
into changes of the NADH levels. The patented optical technology
(CritiView) is based on continuous, real-time concurrent monitoring
of four critical parameters from the same tissue volume by one single
probe. These parameters: NADH redox state, microcirculatory blood
flow, microcirculatory blood oxygenation and tissue reflectance
are highly correlated to tissue viability.
The CritiView illuminates tissue by low power light and detects
light that is subsequently emitted
therefrom.The light is guided to the tissue by a bundle of flexible
optical fibers and emitted from the tissue both by reflection and
fluorescence. The emitted light is collected by the same bundle
of optical fibers that are combined in a proprietary probe. The
detected optical signals are converted into electronic signals,
which are in turn processed by the central-processing unit. The
light emitted from the tissue is comprised of four separate components:
| 1. |
A Doppler shifted reflected light, at the excitation
wavelength, indicative of microcirculatory blood flow (TBF). |
| |
| 2. |
Total back scattered or reflected light,
correlated to blood volume at the observed tissue block. |
| |
| 3. |
Fluorescence light, emitted by intracellular NADH, indicative
of the cellular mitochondrial function and of the tissue's metabolic
state. This constitutes a novel marker for the energetic state
of the tissue. |
| |
| 4. |
Reflected light (at 2 specific wavelength) affected by
the level of hemoglobin oxygenation at the microcirculation
level. |
In-Vivo
Tissue Spectroscopy
|
